The final proposed mechanism of RBC vasodilation from the existence of nitrite would be the reduction of nitrite to NO by Hb. Brooks initial researched the nitrite Hb conversation in 1937 which perform was afterwards prolonged by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to kind metHb and NO (Brooks, 1937